About Monoclonal Antibody Service

An antibody is a protein that attaches itself to an antigen and can be used to detect or purify the target. Antibodies are very useful tools in biochemistry, molecular biology, and medicine, including diagnosis and treatment of illnesses such as cancer and infectious diseases. Laboratory-made antibodies are referred to as monoclonal, or mAbs, because they are exact copies of single antibodies produced by our immune system. Monoclonal antibodies (mAbs) may be given as therapy alone or combined with other treatments such as radiation or chemotherapy drugs.

Monoclonal Antibody Service can also be engineered to serve as delivery vehicles for other medicines. For example, some monoclonal antibodies are used to connect to cancer cells and flag them for attack by our immune systems. Other monoclonal antibodies are combined with cancer-killing chemicals to deliver the drugs directly to the cancer cells, without affecting healthy cells.

Polyclonal Antibody Production Services: When and Why to Use Them

SYSY specializes in developing monoclonal antibodies for research, diagnostics and therapeutics using advanced discovery platforms, such as hybridoma and phage display technologies. Fully custom protocols are developed to match the unique specifications of each project. Antibody characterization and validation approaches include ELISA, WB, FACS, IHC, cell-based screening and affinity ranking.

Creating monoclonal antibodies requires growing B lymphocytes that produce the desired antibodies in large numbers. This is done by selecting antigen-specific plasma/plasmablast cells and fusing them with myeloma cells. The resulting hybridoma cells are screened to identify those that produce antibodies against the target antigen. The selected cells are expanded for mAb production and long term storage using limiting dilution techniques to ensure clonality.…