Our AQP11 antibody catalog includes antibodies against human, canine, porcine, monkey and mouse aquaporin-11 protein. These antibodies are available in different sizes and conjugations.

The AQP11 antibody catalog protein is an intracellular aquaporin that mediates water transport across cell membranes in neurons and other cells. It is a member of the AQP family and has a molecular weight of 30.2 kDa. The protein contains a central pore and four transmembrane segments. AQP11 is known to form heteromultimeric complexes and can exist as monomer or oligomer depending on its function in various tissues.

Despite the presence of multiple aquaporins in brain tissue, it remains unclear how they are differentially localized between different cell types or organs. Previous studies showed that AQP11 is not localized on the plasma membrane but rather remains intracellular in some cells and tissues [15].

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In the present study, AQP11 expression was analyzed in the brains of zebrafish larvae by immunohistochemistry. RNA was isolated from 24-h postfertilization embryos using an RNeasy (r) Mini kit (Qiagen, MD). In vitro transcribed 5′-capped mRNAs encoding GFP and AQP11 with Cys101 mutated to Ala (hAQP11-C101A) were injected into each fish. RT-PCR was performed on the isolated RNA with an amplification reaction using an Optical qPCR System (Ambion, USA).

AQP11 mRNA and protein were expressed in brain tissues from wild type mice at postnatal day 28 days (P28) but to much lesser extent than in kidney and thymus. Moreover, the loss-of-function Cys227Ser mutation of AQP11 induced severe polycystic kidney disease by one month old in Aqp11sjds/sjds mice, which were also found to be susceptible to glucose-induced oxidative stress in the kidney.